BUCCAL FAST DISSOLVING FILM THESIS

They disintegrate rapidly, delivering the medication by oromucosal absorption. In Vitro Dissolution Study drug release rate study: The pH was noted after bringing the electrode of the pH meter in contact with the surface of the formulation and allowing equilibrating for 1. The authors express their gratitude to Dr. Percentage elongation can also be useful to find out the elasticity as well as the strength of a film. We also retain data in relation to our visitors and registered users for internal purposes and for sharing information with our business partners. Related article at Pubmed , Scholar Google.

Evaluation of prepare fast dissolving oral films: Received 9 January In this context, orally disintegrating systems have been studied quite extensively and received greater attention in recent times. Hyperlink reference not valid. Film Thickness The thickness of each of 10 film of each type of formulation was measured using a micrometer screw gauge6 and the average was determined as shown in Table no. The experiments were carried out in triplicate and the average value was taken. The value of the folding endurance was calculated by counting the number of folds made at the same place without the film breaking.

Drug-release studies of the fast-dissolving buccal films of metformin were carried out by using bucal single-bucket United States Pharmacopeia type I basket apparatus containing mL of pH 6.

[Full text] Development of polymer-bound fast-dissolving metformin buccal film wit | IJN

Polymeric strips containing sparfloxacin for the long term treatment of periodontitis. Lindgren S, Janzon L. X1 formulation shows maximum in- vitro drug release Received 9 January The film took approximately 48 hr to dry at controlled room temperature.

buccal fast dissolving film thesis

Formulation and In vitro evaluation of taste masked orodispersible tablet of metoclopromide hydrochloride using indion Films were evaluated for mechanical properties, Morphology study, dissolvign properties, disintegration time, dissolution time and in- vitro drug release.

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The various parameters evaluated for all the formulated films are represented in Table 2.

But, the dissolution test revealed that the most effective immediate release was demonstrated by formulation F6, due fastt the combined effect of two different disintegrants, SSG and MCC. The aim of this study is to formulate and evaluate the FDOF of an anticholinergic drug Dicyclomine and improved bioavailability of drugs as buccwl to conventional solid oral dosage forms. Oral transmucosal drug delivery — current status and future prospects.

Folding endurance of the buccal films was determined by repeatedly folding one film 16 at the same place till it broke or was folded up to times manually, which fasg considered satisfactory to reveal good film properties. Film strip of dimension 2 X 2 cm2 and free from air bubbles or physical imperfections was held between two clamps positioned at a distance of 3 cm apart.

Bhagvati ST, kuppasad IJ. The bioavailability and disintegration properties of OTFs in saliva are increased by adding different ratios of super-disintegrants such as starch, sodium bhccal glycolate SSGand microcrystalline cellulose MCC.

Weights were gradually added to the pan to increase the pulling force till the film was broken.

Development of buccal tablets of diltiazem HCL. The concept of Fast Dissolving Drug Delivery System bucca, from the desire to provide patient with a conventional mean of taking their medication.

The average weight of the films was calculated. Accept In order to provide our website visitors and registered users with a service diszolving to their individual preferences we use cookies to analyse visitor traffic and personalise content. We did not observe any substantial increase in thickness with respect to variations in weight attributed to the addition of disintegrants. However, we did observe that the thickness of all formulations F1—F6 showed a slight increase in thickness as compared to the thickness of formulation F7, without disintegrants.

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The measured surface pH was found to be close to neutral in all the formulations which means that they have less potential to irritate the buccal mucosa and therefore they should be fairly comfortable. Dahima R, Sharma R. All Published work is licensed under a Creative Buccall Attribution 4.

Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

Dissolution medium pH 6. The percent moisture loss was determined by placing prepared film in desiccators containing anhydrous calcium chloride. The presence of the hydrophilic polymer, PVA seems to increase the surface wettability and swelling of the films.

Accessed March 17, Evaluation of prepare fast dissolving oral films: The amount of drug present in the films was determined by dissolving the film in mL of phosphate buffer pH 6. J Pharm Pharm Sci.

buccal fast dissolving film thesis

In this context, several research groups have highlighted the importance of oral transmucosal drug delivery and its future prospects over conventional oral drug-delivery systems. Metformin was chosen as the model drug based on its physicochemical properties and pharmacological action.

BUCCAL FAST DISSOLVING FILM THESIS

All Published work is licensed under a Creative Commons Attribution 4. To this, a calculated amount of metformin mg , disintegrating agents — sucrose, citric acid, and glycerol — were added and diluted to 20 mL using double-distilled water. Design and evaluation of propranolol hydrochloride buccal films. Home Journals Why publish with us? Amidated pectin-based wafers for econazole buccal delivery: Buccal mucosa as a route for systemic drug delivery:

The films were also subjected to in vitro dissolution study, and the disintegration time was found to be less than 30 minutes for all formulations, which was attributed to the effect of disintegrants. Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives. The rate of drug absorption is also dependant on various factors, like the nature of the drug, its formulation, and its interaction in in vivo conditions, which necessitates the development of fast-dissolving systems using polymers for their effective role as drug carriers. The assay of the chosen drug metformin hydrochloride was validated and found to be Editor who approved publication: The difference in release profile was due to the incorporation of different disintegrants in various ratios. The surface pH of the buccal films was confirmed with a pH meter.

X1 was the best formulation showed Metformin hydrochloride Metan antidiabetic drug, has poor bioavailability due to its high solubility and low permeability. The experiments were carried out in triplicate and the average value was taken.

The Physiodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system. Oral thin films OTFs are one such disintegrating system, which are instantly drenched by saliva and adhere to the site of application.

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Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

This would increase the bioavailability of the drug at the required site vuccal action and bring about immediate pharmacological action. The type of the polymer is characterized by following table: Formulation and evaluation of buccal films of salbutamol sulphate. Taste mask, design and evaluation of an oral formulation using ion exchange resin as drug carrier.

Eudragid RL were smooth in texture, flexible and slightly translucent.

buccal fast dissolving film thesis

The percent elongation was calculated by using formula- mm-2 as given below, and the gilm are shown in table no. This could be attributed to the higher rate and extent of swelling of the larger proportion of the hydrophilic polymer, PVA.

[Full text] Development of polymer-bound fast-dissolving metformin buccal film wit | IJN

The drug content was then determined by UV spectrophotometer at nm. Compatibility studies The drug-polymer compatibility was confirmed by taking IR spectrum and DSC thermogram of drug, polymer and physical mixture of drug-polymer proved that the excipients were compatible with the Dicyclomine as shown in figure: Anders R, Merkle HP. In order to provide our website visitors and registered users with a service tailored to their individual preferences we use cookies to analyse visitor traffic and personalise content.

Compatibility between a drug-polymer and different disintegrants was compared using Fourier transform infrared spectra. Oral transmucosal drug delivery — current status and future prospects. Development of buccal tablets of diltiazem HCL.

buccal fast dissolving film thesis

We did not observe any marked differences between formulations F1—F6. A cardboard was attached on the surface of the clamp via a double sided tape to prevent the film from being cut by the grooves of the clamp. These novel drug-delivery systems are a rapid and an efficient approach toward therapeutic applications. Int J Chemtech Res. In this context, orally disintegrating systems have been buccaal quite dissolvinv and received greater attention in recent times.

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The mechanical properties of the film gives idea about to what extent the film can withstand the force or stress during processing, packaging, transport and handling. Fast dissolving oral films: The film took approximately 48 hr to dry at controlled room temperature. Bioadhesive polymer buccal patches for dissolvjng controlled delivery formulation in vitro adhesion and release properties.

Swelling, mechanical andbioadhesive properties.

Therefore, the purpose of the study reported here was to develop a polymer chitosan -based oral disintegrating systems of metformin in the form dissopving thin films. X1 formulation shows maximum in- vitro drug release Hyperlink reference not valid. The force was measured when the films broke results is shown in table no.

The release exponent n describing the mechanism of drug release from the matrices was calculated by regression analysis using the following equation.

buccal fast dissolving film thesis

Disintegration and dissolution time was measure results are shown in table no. J Pharm Pharm Sci.